Durham the fourth-largest city in North Carolina, and the 85th-largest in the United States by population. It is the home of Duke University and North Carolina Central University.
The Eno and the Occaneechi, related to the Sioux, and the Shakori lived and farmed in the area which became Durham. They may have established a village named Adshusheer on the site. The Great Indian Trading Path has been traced through Durham, and Native Americans helped to mold the area by establishing settlements and commercial transportation routes.